lectins and insulin resistance

Introduction. insulin resistance is a pathological state in which insulin action is impaired in target tissues including liver, skeletal muscle, and adipose tissue.. leptin is a hormone produced by your fat cells. measuring how much leptin is in your body tells your brain if enough fat is currently stored… Higher concentrations of this plant lectin, as well as of concanavalin a, competitively displace the binding of insulin to receptors in these tissues. these effects are equally apparent in insulin-binding proteins solubilized from membranes, indicating that the plant lectins interact directly with insulin receptors.. Wheat lectin and "chitin-binding lectin" are therefore functionally identical. this is probably news to most people, and could be an important tidbit for anyone struggling with celiac disease, or any other gastrointestinal issues. be careful if you have insulin resistance.

Lectins appear to interfere with leptin receptors, blocking leptin’s effect of controlling appetite/satiation. this may lead to an increase in glucose in the blood and start insulin resistance (type ii diabetes) in some people. lectins may also contribute strongly to the metabolic syndrome.. The more lectins we eat, the more the receptors for insulin in our muscles are filled with wga and other lectins. so, of course, the more our muscles waste away. finally, when lectins block the insulin receptors in nerve cells, they block the entrance of sugar there, too.. Insulin resistance occurs when more insulin is required to maintain a normal level of blood glucose, and potentially when there is a decrease in insulin receptors in the brain, meaning that those high levels of circulating insulin don’t decrease appetite the way they are supposed to..

IR_Leptin-Lectin

Leptin resistance is similar to insulin resistance in type 2 diabetes, in which the pancreas produces large amounts of insulin, but the body doesn’t respond to it properly.. Aims/hypothesis. decreased sensing of the innate immune system may lead to chronic activation of the inflammatory cascade. we hypothesised that mannan-binding lectin (mbl) deficiency may confer risk of obesity and insulin resistance.. We further propose lectins as a cereal constituent with sufficient properties to cause leptin resistance, either through effects on metabolism central to the proper functions of the leptin system, and/or directly through binding to human leptin or human leptin receptor, thereby affecting the function..

Aims/hypothesis. decreased sensing of the innate immune system may lead to chronic activation of the inflammatory cascade. we hypothesised that mannan-binding lectin (mbl) deficiency may confer risk of obesity and insulin resistance.. Higher concentrations of this plant lectin, as well as of concanavalin a, competitively displace the binding of insulin to receptors in these tissues. these effects are equally apparent in insulin-binding proteins solubilized from membranes, indicating that the plant lectins interact directly with insulin receptors.. Insulin resistance occurs when more insulin is required to maintain a normal level of blood glucose, and potentially when there is a decrease in insulin receptors in the brain, meaning that those high levels of circulating insulin don’t decrease appetite the way they are supposed to..